The National Institutes of Aging (NIA) has approved the second year of funds for ADMdx’s $2 million Small Business Innovation Research grant. This work focuses on the development of a diagnostic product to detect the effects of Traumatic Brain Injury due to repetitive head impact and differentiate them from dementias such as Alzheimer’s disease. ADMdx is collaborating on this work with Dr. Charles Bernick of the Cleveland Clinic, lead investigator of the Professional Athletes Brain Health Study, Dr. Robert Stern of Boston University, lead investigator of the DIAGNOSE-CTE professional and college football study, and other leading researchers. Up to 300 million persons worldwide are affected by repetitive head impact (RHI), including those in contact sports such as football and soccer, military personnel, and those incurring falls or domestic violence. RHI can cause a cascade of events in the brain affecting mood, thinking, and physical abilities, and in a subset of cases leading to a devastating condition called Chronic Traumatic Encephalopathy (CTE). ADMdx’s product would address the problem that there is no diagnostic test available during life, supporting intervention, therapeutic development, and care.