CorInsights® MRI is our FDA-cleared diagnostic report that provides exceptional insights into brain volumes. Numerous published studies have shown that various brain conditions, such as Alzheimer’s disease, are often associated with volume loss in certain brain region combinations. Using a standard MRI scan, our CorInsights® MRI report quantifies which, if any, brain regions have reduced volume compared to an age- and sex-matched normative reference. It translates complexity to clarity by integrating this information into a clear overall view of effects. This insight is intended to aid the medical professional as an adjunct to clinical assessment.
CorInsights® MRI provides an illustrated, quantitative report to aid in the assessment of patient brain status. CorInsights® MRI:
Feedback from neurologists, gerontologists, and other medical professionals who have evaluated CorInsights® MRI
CorInsights® MRI shows the overall picture as well as the detailed quantitative measures that support findings. Shown at left, see on page 1 the overall pattern of effect as a color-coded image and by name, as well as percentile plot and information regarding other attributes.
On page 2 of the reports, find patient-friendly aging curves, showing how their volumes compare to the normative reference in major regions
On page 3, review the segmentation of major lobes, and see percentile and z-core results for the subvolumes that are color-coded in the image on page 1
On page 4, see additional quality control information and any cautions noted during CorInsights® MRI measurement, as well as a summary of methods
Volumes measured by CorInsights® MRI have been tested using cognitively normal, amyloid-negative subject scans, as well as data sets expected to have volumes in certain region combinations below the normative range based upon well-established literature. Our data sets include individuals with amyloid status confirmation and clinical diagnoses of:
Mild Cognitive Impairment
Late Onset Alzheimer's disease
Early Onset Alzheimer's disease
FrontoTemporal Dementia: Behavioral
FrontoTemporal Dementia: Semantic
Posterior Cortical Atrophy
CorInsights® MRI values were compared to the expected percentile and z-score ranges for these data sets and were confirmed to be in these ranges. Relationships between regions were also found to be in agreement with published literature.
In the development of the CorInsights® MRI normative reference database, data were extensively screened to ensure that CorInsights® MRI normative values are not influenced by disease, and consisted of: