ADMdx will present findings regarding the presence of tau, an abnormal protein, in Alzheimer’s patients, at the Tau2020 conference to be held in Washington DC on February 12.  This work describes the diverse burden of tau in individuals with Alzheimer’s disease, and relationships to brain atrophy, glucose metabolism, age, gender, and clinical status.

ADMdx will present findings regarding relationships between tau, glucose metabolism, brain atrophy, and patient characteristics at the ADPD conference in April 2020. These analyses used a unique data set acquired through the Phase II study of the drug rasagiline in Alzheimer’s disease patients in collaboration with Dr. Jeffrey Cummings of the Cleveland Clinic. The data provides new insights regarding these biomarkers in Alzheimer’s disease.

Dawn Matthews, CEO, presented results of ADMdx’s analysis of image data for a Phase II clinical trial of the drug rasagiline in Alzheimer’s disease patients at the Clinical Trials in Alzheimer’s Disease (CTAD) conference in San Diego.  The trial was led by Dr. Jeffrey Cummings of the Lou Ruvo Center for Brain Health at the Cleveland Clinic, in collaboration with the Alzheimer’s Disease Cooperative Study (ADCS) and the Alzheimer’s Drug Discovery Foundation (ADDF). ADMdx’s analysis of FDG PET data showed that rasagiline favorably affected glucose metabolism in frontostriatal regions of the brain, meeting the study’s primary endpoint. Clinical results also showed improvements in Quality of Life and in cognition associated with executive function.

Dawn Matthews, ADMdx CEO, was one of three speakers in an invited panel presentation at the Alzheimer’s Drug Discovery Foundation (ADDF) luncheon on November 1, 2019 in New York.  The panelists described the results of their studies, each focused on repurposing currently approved medications for use in Alzheimer’s disease. Ms. Matthews related the successful outcome of the Phase II clinical trial of rasagiline, led by Dr. Jeffrey Cummings of the Cleveland Clinic.  Image analyses were performed by ADMdx.

New results from ADMdx’s collaborative work on the Down syndrome Biomarker Initiative (DSBI) study led by Dr. Michael Rafii of the University of Southern California has been published.  These results show the correlation between imaging biomarkers and increases in NeuroFilament Light (NF-L), a blood-based marker of neurodegeneration. The manuscript is published in the journal Alzheimer’s & Dementia, titled “Plasma Neurofilament Light and Alzheimer’s Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)”.

ADMdx will present the results of machine learning classification of different Alzheimer’s disease variants and non Alzheimer’s dementias using three different modalities:  structural MRI, glucose metabolism using FDG PET, and early timeframes of amyloid PET scans.  This work was conducted in collaboration with researchers from the Memory and Aging Center of the University of California, San Francisco. The research will be presented orally on July 25th at the Alzheimer’s Association International Conference in Chicago.

ADMdx will present the results of machine learning classification of brain images from impaired and unimpaired boxers, and their differentiation from Alzheimer’s disease images, at the Alzheimer’s Association International Conference on July 22, 2018. This work was conducted in collaboration with Dr. Charles Bernick and other researchers at the Cleveland Clinic, using structural MRI scans from fighters acquired through the Professional Fighters Brain Health Study.

ADMdx has been awarded a Small Business Innovation Research grant from the National Institutes of Aging, focused on the prediction of tau burden in the brain using MRI scans and machine learning.  PET tracers for tau have made it possible to measure abnormal tau accumulation, one of the hallmark pathologies of Alzheimer’s disease.  Using tau PET scans and structural MRI scans from the same patients, ADMdx will explore the ability to use structural MRI, a broadly available imaging technology, to predict the presence and distribution of abnormal tau.

The results of our collaborative work led by Dr. Lisa Mosconi at Weill Cornell Medical School have been published in the April issue of the journal Neurology. Findings showed that lower adherence to a Mediterranean diet was associated with progressive abnormalities in glucose metabolism (measured using FDG PET imaging) and in amyloid (measured using amyloid PET imaging). These data support further investigation of dietary interventions for protection against brain aging and AD.

Our collaborative work led by Dr. Lisa Mosconi of Weill Cornell Medical College has been published in the March issue of the British Medical Journal, titled “Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area”.  In this study, brain image analysis showed that a Mediterranean diet and insulin sensitivity explained reductions in the thickness of gray matter in key brain regions for Alzheimer’s disease. This work has important implications for the role of life style factors, particularly diet, in Alzheimer’s disease risk.