Preclinical studies

ADMdx provides imaging studies using preclinical models, from rodent to nonhuman primate.  We work with a select set of partners for data collection and animal husbandry.  All data are quality controlled, processed, and analyzed centrally by ADMdx.

Advantages of preclinical imaging:

Rapid, translational data regarding…

  • biodistribution
  • pharmacokinetics
  • pharmacodynamics

Animal models:

  • mouse
  • rat
  • nonhuman primate

Advantages of nonhuman primate models:

  • Developed dorsolateral prefrontal cortex as compared to rodents, allowing higher cognitive functions
  • Blood brain barrier similarity to humans
  • Hormonal / reproductive cycle similarity to humans
  • Ability to employ cognitive tasks that can be implemented for human subjects